Mixed germ cell tumor infiltrating the pineal gland without elevated tumor markers: illustrative case.

Koji Shiomi,Yoshiki Arakawa,Sachiko Minamiguchi, Haruki Yamashita,Yukinori Terada,Masahiro Tanji,Yohei Mineharu,Katsutsugu Umeda,Megumi Uto,Junko Takita,Hironori Haga,Takashi Mizowaki,Susumu Miyamoto

Journal of neurosurgery. Case lessons（2021）

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摘要

Careful examination of all tumor specimens and immunohistochemical analyses are important for accurate diagnosis of pineal tumors.

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关键词

AFP = alpha-fetoprotein,CRX = cone-rod homeobox,CSF = cerebrospinal fluid,DWI = diffusion-weighted imaging,GCT = germ cell tumor,Gd = gadolinium,ICE = ifosfamide, cisplatin, and etoposide,MRI = magnetic resonance imaging,N/C = nuclear-cytoplasmic ratio,OCT3/4 = octamer-binding transcription factor 3/4,PLAP = placental alkaline phosphatase,PPTID = pineal parenchymal tumor of intermediate differentiation,SALL4 = Sal-like protein 4,T1WI = T1-weighted imaging,T2WI = T2-weighted imaging,histological diagnosis,immunohistochemistry,mixed germ cell tumor,pineal parenchymal tumor of intermediate differentiation,pineocytoma,β-HCG = beta-human chorionic gonadotropin

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