Effects of metformin on lymphocyte DNA damage in obese individuals among Kazakh population

Khatimya Kudabayeva,Raikul Kosmuratova,Yerlan Bazargaliyev, Aigul Sartayeva,Nurgul Kereyeva

Diabetes & Metabolic Syndrome: Clinical Research & Reviews（2022）

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摘要

•DNA damage monitoring can become an important part of clinical studies in obesity.•The use of metformin 850 mg/day for the treatment of obesity results in a decrease in DNA breaks in the serum lymphocytes.•Studies in humans with somatic cells have shown evidence of increased DNA damage with high BMIs.

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关键词

Body mass index,Genetic material,Genome instability,Oxidative stress,Obesity epidemic

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