Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2022)
Abstract
Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in P. aeruginosa.
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Key words
SCV, antibiotic resistance, tobramycin, gentamicin, burn wound infection, Pseudomonas aeruginosa, small-colony variant, aminoglycosides
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