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Clinical characteristics, disease evolution and survival in patients with chronic myeloid leukemia, BCR-ABL1 (+) and T315I mutation.

Veselina Goranova-Marinova,Alexander Linev,Hristo J Ivanov, Ivan Zheljazkov, Vily Stoyanova,Zhanet Grudeva-Popova

Folia medica（2021）

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Abstract
Our data confirm the world experience on the frequency of T315I mutation, including the unfavourable evolution, resistance to TKI treatment and short survival. ddPCR is a highly sensitive method for early detection of genetic mutations which gives the chance for effective treatment.
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Key words
CML,clinical evolution,mutation T315I
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