Modulation of diabetic kidney disease markers by an antagonist of p75NTR in streptozotocin-treated mice

Bryan E. Luu,Abubakr H. Mossa,Philippe G. Cammisotto,H. Uri Saragovi,Lysanne Campeau

Gene（2022）

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摘要

•p75NTR antagonists were previously studied for diabetic retinopathy.•p75NTR antagonism may be beneficial for diabetic kidney disease (DKD)•Antagonists such as THX-B modulated kidney gene expression tightly linked with DKD.•Creatinine, urea, and markers of fibrosis/inflammation suggest improvements to DKD.•Clinical translation of p75NTR antagonists for DKD warrants further investigation.

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关键词

Type 1 diabetes,proNGF,P75NTR,Diabetic kidney disease,Therapeutic agents,microRNAs

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