Cyclization/hydrolysis of 1,5-enenitriles initiated by sulfonyl radicals in the aqueous phase in the presence of the I-2/TBHP system
Organic & Biomolecular Chemistry(2022)
Abstract
A novel cyclization/hydrolysis of 1,5-enenitriles for the synthesis of valuable pyrrolidine-2,4-diones in the aqueous phase using I-2 as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant is reported. In the presence of the I-2/TBHP system, sulfonyl hydrazides produce sulfonyl radicals, which undergo radical addition, intramolecular cyclization, hydrogen abstraction, and hydrolysis to give the final products. The use of the inexpensive and environmentally friendly I-2/TBHP catalytic oxidation system in the aqueous phase makes it a benign and sustainable strategy.
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Key words
sulfonyl radicals,cyclization/hydrolysis,cyclization/hydrolysis,aqueous phase
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