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Histamine H3R antagonist counteracts the impaired hippocampal neurogenesis in Lipopolysaccharide-induced neuroinflammation

Jiangong Wang,Bin Liu,Fengjiao Sun,Yong Xu,Haiyun Luan,Meizi Yang,Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou,Haijing Yan

International Immunopharmacology（2022）

Cited 7|Views6
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Abstract
•Inhibition of H3R suppresses the lipopolysaccharide-induced neuroinflammation.•Inhibition of H3R counteracts the neuroinflammation induced impairment of neurogenesis.•Inhibition of H3R ameliorates the lipopolysaccharide-induced cognitive impairment.•The neuroprotection of H3R antagonist is mediated by histamine dependent activation of H2R/CREB pathway.
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Key words
Histamine H3 receptor,Aging,Microglia,Neuroinflammation,Neurogenesis,CREB
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