Sudden winter iloprost withdrawal in scleroderma patients during COVID-19 pandemic

•Coronavirus pandemic provided unrepeatable circumstances close to an experimental condition to assesses the effect of iloprost withdrawal in scleroderma.•Low capillary density at capillaroscopy can predict an early worsening of both Raynaud’s phenomenon and digital ulcers after iloprost discontinuation.•Capillaroscopy could be used to personalize Iloprost regimens in scleroderma patients.