Daily Inhaled Corticosteroids Treatment Abolishes Airway Hyperresponsiveness to Mannitol in Defence and Police Recruits.

Clair D Lake,Keith K H Wong,Clare P Perry,Heikki O Koskela,John D Brannan

Frontiers in allergy（2022）

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摘要

Airway hyperresponsiveness to mannitol can be abolished after 20 weeks of daily treatment with ICS. Inhibition of AHR is likely due to attenuation of airway inflammation in response to ICS treatment. Increased airway reactivity and lower spirometry variables predicted the persistence of AHR. Thus, those with a slower response to daily ICS on AHR can potentially be identified at the commencement of monitoring ICS using inhaled mannitol.

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关键词

airway hyperresponsiveness (AHR),asthma,indirect bronchial challenge test,inhaled corticosteroids,occupational assessment

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