Effects of trabectedin in the zebrafish Danio rerio: from cells to larvae

Évila Pinheiro Damasceno,Ives Charlie-Silva,Glaucia Maria Machado-Santelli,Anali M.B. Garnique,João Agostinho Machado-Neto,Simone Aparecida Teixeira,Paula C. Jimenez,Diana Carneiro,Amadeu M.V.M. Soares,Leticia V. Costa-Lotufo,Susana Loureiro,Maria D. Pavlaki

Environmental Advances（2022）

引用 3|浏览6

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摘要

•Cytotoxicity occurred in ZFL-cells exposed to trabectedin.•Trabectedin caused morphological alterations in ZFL-cells.•Trabectedin caused mortality and malformations in Danio rerio embryo-larvae.•Locomotor impairments in Danio rerio larvae were induced by trabectedin.•The zebrafish larvae-cell line system can be a suitable tool for AAs ecotoxicology.

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关键词

Anticancer agent,Zebrafish locomotor behavior,ZFL cells,Developmental toxicity,Cytotoxicity

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