Generation of an induced pluripotent stem cell line (MUSIi015-A) from a diabetic patient carrying mutations in ZYG11A (p.L475P) and GATA6 (p.E51K)

Stem Cell Research(2022)

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Abstract
•A mutation (p.L475P) in ZYG11A completely segregating with hyperglycemia in a family with autosomal dominant diabetes was reported as a cause of cell cycle arrest and a reduced growth rate of beta-cells.•We generated an iPSC line from a diabetic proband with ZYG11A and GATA6 mutations.•This iPSC line is a useful resource for modeling familial diabetes of the adulthood.•We generate an iPSC line derived from a diabetic proband carrying ZYG11A-p.L475P and GATA6- p.E51K mutations.•The established line of iPSCs is a fruitful resource for modeling diabetes associated with the two mutations.
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Key words
Familial diabetes of the adulthood,Autosomal dominant diabetes,ZYG11A,GATA6,iPSC
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