Analytical techniques for characterizing diastereomers of phosphorothioated oligonucleotides

Tao Chen,Shijia Tang,Yige Fu,José G. Napolitano,Kelly Zhang

Journal of Chromatography A（2022）

引用 8|浏览4

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摘要

•Overviewed configuration, properties, synthesis of PS oligonucleotide diastereomers.•Reviewed analytical methods for PS oligonucleotide diastereomer characterization.•Included LC (IP-RP, AEX, MMC, hybrid), CE, spectroscopy, and other methods.•Discussed factors influencing the IP-RP diastereomer selectivity and retention.

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关键词

Oligonucleotide therapeutic,Phosphorothioate modification,Stereo-selective synthesis,Diastereomer characterization,Oligonucleotide analysis

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