Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance
Journal of Diabetes Investigation(2022)
摘要
In a recent article published in Nature, Chen et al. reported that pregestational hyperglycemia rendered offspring vulnerable to glucose intolerance due to insufficient TET3-mediated 5-methylcytosine oxidation and DNA demethylation, resulting in hypermethylation and reduction of insulin-secreting genes.
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