Borrowing Hydrogen Amination Reactions: A Complex Analysis of Trends and Correlations of the Various Reaction Parameters br

Borrowing hydrogen or the hydrogen autotransfer amination is apowerful approach to create single C-N bonds, starting from stable and readilyavailable substrates: amines and alcohols. It is considered as one of the most atom-efficient and green methods to synthesize complex amines. Herein, we attempted toarrange the array of the existing data in a comprehensive and structured manner anddetermine correlations between the experimental conditions and catalysis outcomeboth within different groups of catalysts and between the defined groups using themachine analysis. For each type of N-nucleophiles (aromatic, aliphatic, andheteroaromatic amines, amides), the most efficient working conditions were suggested, including attributing the optimal base and temperature regime for each metal.