Cell-Type Specific Methylation Analysis Reveals Multiple Loci Associated With PTSD in African Americans

Seyma Katrinli,Agaz Wani,Aarti Gautam,Rasha Hammamieh,Ruoting Yang,Varun Kilaru,Adriana Lori,Abigail Powers,Rebecca Hinrichs,Charles F. Gillespie,Aliza P. Wingo,Vasiliki Michopoulos,Tanja Jovanovic,Marti Jett,Monica Uddin,Kerry Ressler,Alicia Smith

Biological Psychiatry（2022）

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摘要

Multiple studies identified DNA methylation differences in immune-related genes in PTSD. Immunologic studies of leukocytes in individuals with PTSD reported elevated lymphocyte, total T cell, and CD4+T cell counts. Thus, correcting for cell-type composition in epigenomic studies may obscure some PTSD-associated signals. This study leverages a new bioinformatic method to identify novel DNA methylation patterns associated with PTSD in specific cell-types.

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关键词

PTSD, Inflammation, DNA Methylation, Cell Type Specific EWAS

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