Effect on Healing Potential of Biosynthesized Silver Nanoparticles in Streptozotocin induce Diabetic Rat Wound Model

Background: Diabetes mellitus is a complex chronic condition that results in hyperglycemic environment affecting the metabolism of proteins and lipids, promotes inflammation and delays wound healing. Methods: A total of n=30 Wistar rats of either sex were divided into five groups with 6 animals in each. Diabetes mellitus was induced using streptozotocin @ 35 mg/kg body weight and excision wound model was developed in all the animals. Group I and Group II were considered as healthy and diabetic control group respectively. The wounds of Group III, IV and V were treated with topical application of Carica papaya synthesized silver nanoparticles @ 62.5 mu g/ml, Carica papaya Ieafextract @31.25 mg/ml and 10% povidone iodine respectively. Result: Present study concluded that the characteristics of silver nanaoparticles synthesized form C. papaya leaf extract make them suitable for the treatment of wound healing in diabetic subjects.