Hybrid multilayer coating as the psoralen delivery vehicle promoting bone regeneration on titanium mesh scaffolds in a Posterolateral Spinal Fusion model

Yanlin Chen,Gang Zheng,Yujie Bian,Haiwei Ma,Chenqiang Jin,Zhichao Hu,Haohan Su,Xinli Hu,Zhiyong Qian,Liyan Shen,Wenfei Ni

Applied Materials Today（2022）

Cited 1|Views11

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Abstract

•Polysaccharide/bioceramic multilayer a good small molecule drug delivery system.•Organic/inorganic hybrid multilayer possess cytocompatibility and osteoconductivity.•Psoralen promote osteogenesis via activate autophagy through P62/LC-3 pathway.

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Key words

Psoralen,Layer-by-layer assembly,Autophagy,Surface modification of titanium,Bone regeneration

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