Anandamide regulates vascular adaptations at the maternal-fetal interface in the rat

Worldwide, pesticides form an essential and indispensable component of modern agriculture practices. They can either be synthetic or derived from microorganisms and various botanical sources. Pesticides are extensively employed in agricultural fields to fend off a variety of pests and weeds. The application of these chemicals has increased exponentially in the past century and has led to a revolutionary upswing in harvest yield across the globe. It has been estimated that nearly 3 billion kilograms of these chemicals are utilized every year, and an amount of ~ 40 billion USD is allocated to their purchase.Consequently, pesticides have been responsible for making food more accessible and abundant to individuals of all economic and social classes. Therefore, the importance of pesticides in the global agricultural ecosystem cannot be underestimated. Despite pesticides’ vital role in upholding food security across the planet, their usage has come under intense scrutiny from various nations and environmental agencies. Several commonly used pesticides like chloropyrfios (CPF) and dichloro-diphenyl-trichloroethane (DTT) are non-biodegradable and highly toxic. Unfortunately, human health is severely impacted by pesticide residues, and research has demonstrated the harmful effect of pesticides on various human organs. Chronic exposure to pesticides in humans can lead to respiratory, neurological, digestive, reproductive, and ocular complications. Several reports suggest that pesticides can also cause various types of cancers. Unsurprisingly, agricultural workers are maximally impacted by both acute and chronic exposure to pesticides.Moreover, ingestion of pesticides can be especially fatal and culminates in the death of the individual. Even the normal human populace is affected by pesticides due to a process called biomagnification, where the accumulation of pesticide residues increases at every ascending level of the food chain. Additionally, reports have indicated that prenatal contact to pesticides leads to fetal abnormalities and congenital problems in newborn babies. Therefore, in the light of the plethora of evidence on hand, stringent curbs need to be applied to pesticide usage to limit the hazardous impact of these chemicals on human health.