Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish

Tsubasa Saeki,Sho Yoshimatsu,Mitsuru Ishikawa,Chung-Chau Hon,Ikuko Koya,Shinsuke Shibata,Makoto Hosoya,Chika Saegusa,Kaoru Ogawa,Jay W. Shin,Masato Fujioka,Hideyuki Okano

Regenerative Therapy（2022）

引用 4|浏览13

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摘要

•A 3D floating culture condition is critical for inducing otic placodal cells from hPSCs-derived preplacodal cells.•Activation of FGF, RA, WNT signalling pathways is indispensable for differentiating otic lineage under the 3D condition.•Overexpression of defined transcription factors facilitated the generation of hair cells from hPSCs-derived otic cells.

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关键词

Human pluripotent stem cell,Floating culture,Otic placode,Single cell RNA-seq,Hair cell

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