Enhanced inhibition of breast cancer by a dose reduced- dual anticancer drug loaded CMCS/Au nanocomposite

E. A. K. Nivethaa, S. Sivasankari,S. Baskar,Catherine Ann Martin,N. Sivanandham,Narayana S. Kalkura

Materials Letters（2022）

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摘要

•Unique combination of anticancer drugs (5-Fluorouracil + Doxorubicin) used.•Incorporation of CMCS and Au as drug carriers improves cancer inhibition.•Cytotoxicity of dual drug loaded system comparatively higher than existing systems.•Enhanced, sustained and prolonged drug release leading to dose reduction.•Solubility of CMCS aids in oral delivery.

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关键词

Carboxymethyl chitosan,Gold,Dual drug delivery,Breast cancer

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