Deranged growth factors as a prognosticator of cardiovascular risks in patients with uterine fibroids

Background: Angiogenesis is a crucial factor for the pathogenesis and growth of fibroids. Among various growth factors, transforming growth factor (TGF beta 1) and vascular endothelial growth factor (VEGF) are up-regulated in leiomyomas and have angiogenic as well as pro-atherogenic properties. Subsequently, their elevated values may be involved in developing cardiovascular disorders. Objective: The current study was planned to evaluate the role of growth factors in females with uterine fibroids and investigate the future risks of developing cardiovascular disorders (CVD) in these patients. Method: Eighty-two subjects of uterine fibroids and eighty-two healthy controls were selected from tertiary care hospitals. Enzyme-linked immunosorbent assay (ELISA) was utilized to assess growth factors. Results: The levels of TGF beta 1 and VEGF were significantly higher (P < 0.001) in patients with uterine fibroids compared to healthy females without uterine fibroids. Conclusion: High levels of circulating growth factors in patients with uterine fibroids prognosticate (CVD) events in these patients.