Novel mucoadhesive carriers based on alginate-acrylamide hydrogels for drug delivery
Mendeleev Communications（2022）
Abstract
New mucoadhesive two-component carriers for drug delivery based on synthetic acrylamide/diethylacrylamide and natural alginate hydrogels have been synthesized. The introduction of sodium alginate into polyacrylamide/poly(diethylacrylamide) gels, followed by their crosslinking with metal ions, significantly changed structure and properties of hydrogels, such as swelling degree, drug capacity and drug release rate in physiological solution. The structure of the gels was characterized by FTIR spectroscopy and scanning electron microscopy.
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Key words
two-component hydrogel,interpenetrating networks,polyacrylamide,poly(N,N-diethylacrylamide),sodium alginate,covalent network,ionic network,drug delivery system
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