Tumor-permeated ATP-based size-controllable immunogenic cell death amplifier remodel immunosuppressive microenvironment to boost cancer immunotherapy

•A novel tumor-permeated ATP-based size-controllable immunogenic cell death amplifier (NABP@SNCs) was fabricated for the first time to boost cancer immunotherapy.•ATP was smartly loaded and released into extracellular regions of tumor tissues through pH reversible borate ester bonds between ribose of ATP and phenylboronic acid of platinum nanoparticles (BP) for site-specific immune amplification.•NABP@SNCs could significantly amplify ICD cascade through ATP-assisted dendritic cells recruitment and eventually facilitate antitumor immune response together with NLG919 mediated TIM reversal.•This novel NABP@SNCs will provide a novel viewpoint for cancer immunotherapy and further explore the application of ATP in cancer immunotherapy.