Novel Screening System of Virulent Strains for Establishment of Mycobacterium Avium Complex Lung Disease Mouse Model Using Whole Genome Sequencing

K. Furuuchi,S. Seto,N. Hajime, H. Hikichi,A. Miyabayashi,K. Wakabayashi,K. Morimoto,K. Mizuno,M. Minako Hijikata,N. Keicho

MICROBIOLOGY SPECTRUM（2022）

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摘要

To promote research on Mycobacterium avium complex (MAC) pathogenicity, animal models reflecting human progressive MAC lung disease (MAC-LD) are needed. Because there is high genetic and virulence diversity among clinical MAC strains, choosing a suitable strain is an important process for developing a mouse model.

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关键词

Mycobacterium avium complex,mouse model,granuloma formation,whole-genome sequencing,SNVs,MAC-LD,granuloma

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