Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases

•H2S is a powerful signalling molecule with a diverse physiological role.•As a positive modulator of mitochondrial electron transport chain, H2S interact with many redox reactions and induce post translational modification to proteins via sulfhydration.•With the growing interest and research in the H2S donors and pro-drugs hold a promising future for treating vascular diseases.