Impact of Copper and Oxidative Stress Index Levels on Insulin Resistance, Lipid Profile and Hormonal Status of Patients with Polycystic Ovary Syndrome

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine abnormalities of reproductive age and has a highly heterogeneous nature regarding its multisystemic symptoms. To elicit pathophysiological roots, metabolic mapping and between-correlations among key parameters are of vital importance. We generated a platform including cardinal hormones, lipids, homeostasis model assessment of insulin resistance (HOMA-IR) and oxidative markers [total-oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), copper (Cu)] related to pathophysiology. Methods: This prospective case-control study included 46 patients with PCOS and 44 non-PCOS healthy women. Samples were obtained from the Obstetrics and Gynecology Clinic of University of Health Sciences Turkey, Istanbul Training and Research Hospital. TAS, TOS, and Cu levels were measured by automated methods. Results: Anti-Mullerian hormone, total testosterone (TT), dehydroepiandrosterone sulfate, low-density lipoprotein, high-density lipoprotein (HDL), total cholesterol, TOS, OSI were increased in patients with PCOS with no significant differences in the mean values of other parameters. ROC analysis revealed that TOS and OSI had an acceptable predictive value for PCOS diagnosis. Plasma HOMA-IR, triglyceride, HDL, TT, and sex-hormone-binding globulin levels were correlated with OS markers. Conclusion: Redox status was found to be sensitive to hormonal alterations. Metabolites were then were compared with the oxidative markers to reveal any relationship that may explain the causal link between metabolic and redox changes Ultimately, evaluating broad-based metabolic profiling of patients, the current study contributes to the literature, which has controversial data and correlation findings poses new questions requiring further research to elicit underlying mechanisms and so to set new targets for both prevention and treatment.