Facile synthesis of core-shell structured magnetic Fe3O4@SiO2@Au molecularly imprinted polymers for high effective extraction and determination of 4-methylmethcathinone in human urine samples

In this study, a novel material of core-shell structured magnetic molecularly imprinted polymers (Fe3O4@SiO2@Au (FSA)-MIPs) was successfully prepared for the rapid and selective determination of 4-methylmethcathinone (mephedrone, 4-MMC). The adsorption capacity of FSA-MIPs is 34.7 mg center dot g(-1) at 308 K, which is significantly higher than magnetic non-imprinted polymers profiting from the imprinting effect. The FSA-MIPs have a short equilibrium (20 min) and could be reused more than six times. Moreover, the selectivity coefficients of FSA-MIPs for 4-MMC, 3,4-dimethylmethcathinone, butylone, 4-ethylmethcathinone, acetylfentanyl, and methylene blue are 4.01, 5.65, 7.62, 12.30, and 20.87 respectively, further indicating the markedly enhanced binding selectivity of FSA-MIPs. As an adsorbent, the FSA-MIPs were successfully applied for effective extraction of 4-MMC in three human urine samples with the recovery rates ranging from 85.5-92.6%. The results confirmed that the FSA-MIPs have good prospects in the extraction and separation of synthetic cathinones, which is suitable for further application in the criminal sciences field.