A computational approach to understand the breathing dynamics and pharmaceutical aerosol transport in a realistic airways

•Two phase breathing dynamics has been studied in realistic lower airways.•Flow analysis is carried out and deposition/distribution patterns are depicted.•Majority of particles enter right lung while deposition is higher in left lung.•Distribution of particles to upper lobes reduces due to inertial impaction.•Right upper, left lower and right lower lobes are regions with highest deposition.