A Unified Strategy for the Synthesis of Natural Products Containing δ‐Hydroxy‐γ‐ Lactones through a Photoredox ATRA Reaction.

A unified strategy for the synthesis of natural products containing δ‐hydroxy‐γ‐lactones as the main core is reported. This strategy is based on a photocatalyzed radical ionic sequence for the preparation of γ‐lactones. Depending on the necessities of the synthetic targets, the reaction conditions can be adjusted to access a diastereoisomeric mixture or a single diasteroisomer of the lactones. Also, δ‐lactones can be prepared by this method. The utility of this procedure was demonstrated by the total synthesis of five natural products.