Post-orgasmic illness syndrome accompanied with testosterone deficiency: a case report

Post-orgasmic illness syndrome (POIS) is a rare disease that affects the quality of life of patients. Here, we report a case of a 27-year-old man who visited our clinic and presented with physical fatigue, muscle weakness, emotional irritability, memory difficulties, lack of attention, and flu-like state after ejaculation. The patient was diagnosed with POIS accompanied by testosterone deficiency (TD) and treated with antiallergic therapy combined with testosterone supplementation therapy (TST) and selective serotonin reuptake inhibitor (SSRI). After 3 months of medication, the patient's POIS symptoms, testosterone levels, and relevant questionnaire scores significantly improved. Antiallergic therapy combined with TST and SSRI treatment can effectively treat patients with POIS accompanied by TD.