General Overview of Silent Information Regulator Tow Homolog 1 (SIRT 1) and Its Role in Non Alcoholic Fatty Liver Disease

Background: Nonalcoholic fatty liver disease (NAFLD) is described as lengthy status hepatic steatosis that is not due to genetic, metabolic disorders, infections, side effect of medications, alcohol intake or malnutrition. It has emerged a major challenge because of its prevalence, difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. As the load of hepatitis C decreases over the subsequent decade, (NAFLD) will become the major form of chronic liver disease in adult and children and grow to be the main indication for liver transplantation Sirtuins (Silent Information Regulator Tow Homolog 1) was first find out in 1970s. It is role by eliminating acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD). The sirtuin family, which is broadly spread throughout the nature, has been distributed into seven human isoforms (Sirt 1-Sirt 7).