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Design of cysteine-S-sulfonated keratin via pH driven processes: Micro-Structural Properties, biocidal activity and in vitro validation

Diego O. Sanchez Ramirez,Cinzia Tonetti,Iriczalli Cruz-Maya,Vincenzo Guarino,Roberta Peila,Riccardo A. Carletto,Alessio Varesano,Claudia Vineis

European Polymer Journal（2022）

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Abstract
•Keratin-ligand complexes were produced by pH variation.•Biocidal activity of protonated keratin against S. aureus was demonstrated.•Keratin-lyophilized powder with better thermostability was obtained.•Keratin-secondary structures influenced notably cell-material interactions.
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Key words
Keratin,Biocidal protein,Thermostability,Cell viability,Protein–ligand complexes
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