A novel dual three and five-component reactions between dimedone, aryl aldehydes, and 1-naphthylamine: synthesis and computational studies

•A parallel three and five-component reactions are introduced between dimedone, aryl aldehydes, and 1-naphthylamine.•An unprecedented five-component route to the synthesis of bis(2-benzyl-5,5-dimethylcyclohexane-1,3-dione)-N- and 4- disubstituted naphthylamine derivatives is explored.•Some novel acridine derivatives are presented.•In-silico approaches such as target prediction, molecular modeling, and estimated values of pharmacokinetic factors of synthesized derivatives are investigated.