Synthesis of some oxazolo[4,5-d]pyrimidine derivatives and evaluation of their antiviral activity and cytotoxicity

New oxazolo[4,5-d]pyrimidine derivatives were synthesized and their some physicochemical and ADMET properties were analyzed by in silico prediction. Antiviral activity against DNA viruses (human cytomegalovirus, varicella-zoster virus, herpes simplex virus and BK virus) and cytotoxicity, including control experiments, were evaluated in vitro. Some of the compounds synthesized were characterized by low toxicity; however, they did not exhibit favorable antiviral effects.