Simultaneous multimaterial multimethod bioprinting

Bio-Design and Manufacturing(2022)

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摘要
Bioprinting:a powerful tool to fabricate biomimetic tissues and organs Bioprinting is an important technology in the field of biofabrication that aims to create functional biomimetic structures.The flexibility,versatility and functionality of bioprinting enable the fabrication of intricate biological structures by combining cells,biomaterials or growth factors as printing bioinks [1,2].Conventional bioprinting technologies now face challenges,including the contradiction between the overall mechanic al stability and the biologic al microenvironment of the construct and the vascularization of the printed tissues/organs.People have come to realize that it is unrealistic to build fully functional tissues/organs with just a single material.The complex composition and diversity of native tissues/organs require more than what a single-material bioprinting technique can possibly deliver [3].
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