Comparative assessment of heterogeneous and homogeneous Suzuki-Miyaura catalytic reactions using bio-Profiles and bio-Factors

•bio-Profiles and bio-Factors allow fast estimation of toxic effects of chemical reactions.•Supported palladium catalysts have an advantage over soluble catalysts in terms of toxicity.•The negative environmental impact of supported catalysts is related to their preparation.•Toxic effects of catalyst preparation can be reduced by choosing harmless solvents and avoiding toxic byproducts.