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Pre-existing T cell immunity determines the frequency and magnitude of cellular immune response to two doses of mRNA vaccine against SARS-CoV-2

Jose L. Casado,Pilar Vizcarra,Johannes Haemmerle,Hector Velasco,Adrian Martin-Hondarza,Mario J. Rodriguez-Dominguez,Tamara Velasco, Sara Martin,Beatriz Romero-Hernandez,Marina Fernandez-Escribano,Alejandro Vallejo

Vaccine: X（2022）

Cited 9|Views2
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Abstract
•Lack of CD4 T-cell response to first/second dose of mRNA vaccine was observed in 21% and 12% of health care workers (HCWs).•T-cell response was greater in frequency/magnitude in HCWs with pre-existing immunity, due due to infection or cross-reactivity.•Pre-existing immunity correlated with the magnitude of specific antibodies production after vaccination.
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SARS-CoV-2 humoral response,Cellular response,mRNA vaccine,Pre-existing immunity
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