Synthesis of (Hetero)Aroyl Fluorides via a Mild Amides C-N Bond Cleavage
Advanced Synthesis and Catalysis(2022)
摘要
Amides, such as N-benzoylsaccharin, N,N-diBocbenzamide, and N-phenyl-N-tosylbenzamides reacted with Et3N.3HF to provide the corresponding acyl fluorides in good yields. The reaction was conducted under environmentally friendly conditions using i-PrOAc as the solvent. Moreover, the reaction was performed at room temperature and did not require a transition-metal catalyst or additives. The methodology showed functional group tolerance toward amines, alkoxy, halides, ketones, esters, and aldehydes.
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关键词
amides,N-benzoylsaccharin,fluorides,acyl fluorides,C-N Bond Cleavage
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