cis -Jasmone: Phytopharmaceutical Potential for the Treatment of Skin Inflammation

cis -Jasmone is known to activate plan resistance to insects. There are few reports of its pharmacological potential, and this paper presents the topical anti-inflammatory effect of cis -jasmone. cis -Jasmone reduced the oedema induced by arachidonic acid, capsaicin and phenol, but not by croton oil (single and multiple applications). cis -Jasmone presented a mild effect on the histamine model. The most prominent anti-inflammatory effect of cis -jasmone was found in the oedema model induced by capsaicin (TRPV1 agonist). This effect was preventive and therapeutic, and it was similar to the effect shown by the TRPV1 antagonist capsazepine. Molecular docking studies indicated that cis -jasmone may interact with TRPV1. The effect of cis -jasmone remained after incorporation into the formulation. cis -Jasmone has a topical anti-inflammatory effect related to TRPV1 channel antagonism, and the gel-cream containing this terpene may be an alternative for the treatment of skin inflammation. Graphical abstract