Evaluation of Antibacterial Activity of Calcium Phosphates Based Bone Cements for Biomedical Applications

In orthopedics and traumatology surgeries, the repair of bone deformities is a concern. Pure and Cobalt (Co) doped Calcium phosphate (CaP) cements were successfully prepared in this study. The particles that had been manufactured were characterized. Three different methods were used to study the structure of the materials: X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and Scanning electron microscope (SEM). The lattice characteristics, degree of crystallinity, and particle size of pure CaP bone cement were reduced dramatically with the incorporation of Co2+ ions. The functional groups of CaP bone cements were detected via the FTIR technique. Antibacterial properties of pure and Co doped CaP bone cement were evaluated qualitatively against Escherichia coli (E. Coli, gram -), Methicillin-sensitive Staphylococcus aureus (MSSA, gram +). Methicillin-resistant Staphylococcus aureus (MRSA, gram +), Methicillin-resistant coagulase-negative staphylococci (MR-CoNS, gram +), and Pseudomonas aeruginosa (P. aeruginosa, gram -) bacteria for 24 h at 37 degrees C. After analyzing the data, it was found that the inclusion of Co2+ ions inhibited the growth of E. coli and MSSA bacteria. Antibacterial bone cements are potential material for preventing infection-related bone healing failures.