RAD51 Inhibitor and Radiation Toxicity in Vestibular Schwannoma.

Torin P Thielhelm,Aida Nourbakhsh,Scott M Welford,Eric A Mellon,Olena Bracho,Michael E Ivan,Fred Telischi,Cristina Fernandez-Valle,Christine T Dinh

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery（2022）

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Abstract

VS may evade radiation injury by entering cell cycle arrest and upregulating RAD51-dependent repair of radiation-induced double-stranded breaks in DNA. Although there was variability in responses among individual primary VS cells, RAD51 inhibition with RI-1 reduced RAD51-dependent DNA repair to enhance radiation toxicity in VS cells. Further investigations are warranted to understand the mechanisms of radiation resistance in VS and determine whether RI-1 is an effective radiosensitizer in patients with VS.

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Key words

H2AX,RAD51,RAD51 inhibitor,VS,cell cycle arrest,p21,radiation,resistance,vestibular schwannoma

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