Immunomodulatory activity and active mechanisms of a low molecular polysaccharide isolated from Lanzhou lily bulbs in RAW264.7 macrophages
Journal of Functional Foods(2022)
Abstract
•Lanzhou lily polysaccharides with low molecular weight were extracted from the bulbs by freeze-thaw method for the first time.•The polysaccharides structure was characterized by different physical and chemical experiments.•Cell proliferation, cytokines, and other experiments prove that polysaccharides have immunoactivation of RAW264.7.•RNA-seq and RNAi experiment revealed the immune regulation mechanism of the polysaccharides, it can activate the corresponding signaling pathways in the downstream of the G protein coupled receptor subunit.
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Key words
Lily polysaccharide,Isolation,RNA-Seq,Immune regulation
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