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An ACE inhibitory peptide from Isochrysis zhanjiangensis exhibits antihypertensive effect via anti-inflammation and anti-apoptosis in HUVEC and hypertensive rats

Yu Pei,Shengxuan Cai,Bomi Ryu,Chunxia Zhou,Pengzhi Hong,Zhong-Ji Qian

Journal of Functional Foods（2022）

Cited 6|Views5
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Abstract
•An ACE inhibitory peptide from Isochrysis Zhanjiangensis exhibits (ETT).•ETT can inhibit Ang II-induced inflammation and apoptosis.•ETT (IC50 = 15.08 μM) antagonizes ACE in a non-competitive binding mode.•ETT has an antihypertensive effect in spontaneously hypertensive rats.
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Key words
Isochrysis Zhanjiangensis,Peptide,Hypertension,Angiotensin-I Converting Enzyme,Inflammation,Apoptosis
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