Integrative pharmacogenomics revealed three subtypes with different immune landscapes and specific therapeutic responses in lung adenocarcinoma.

Computational and structural biotechnology journal(2022)

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摘要
We provided a novel molecular classification strategy and revealed three pharmacogenomics-based subtypes for LUAD patients, which uncovered potential subtype-related and patient-specific therapeutic strategies.
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关键词
CCLE, cancer cell cine encyclopedia,CTRP, cancer therapeutics response portal,DRGs, drug response-associated genes,GDSC, genomics of drug sensitivity in cancer,ICBs, immune checkpoint blockers,IGP, in-group proportion,Immune landscapes,LUAD, lung adenocarcinoma,Lung adenocarcinoma,Molecular subtypes,NMF, non-negative matrix factorization,NSCLC, non-small cell lung cancer,PI, proximal inflammatory,PP, proximal proliferative,PRISM, profiling of relative inhibition simultaneously in mixtures,Pharmacogenomics,Precision medication,SubMap, subclass mapping analysis,TMB, tumor mutation burden,TME, tumor microenvironment,TRU, terminal respiratory unit,Therapeutic responses,ssGSEA, single-sample gene set enrichment analysis
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