Soft Tissue Sarcoma, Version 2.2022

Soft tissue sarcomas (STS) are rare malignancies of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic char-acteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of pa-tients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Soft Tissue Sarcoma provide recommendations for the diagnosis, eval-uation, and treatment of extremity/superficial trunk/head and neck STS, as well as retroperitoneal/intra-abdominal STS, desmoid tumors, and rhabdomyosarcoma. This portion of the NCCN Guide-lines discusses general principles for the diagnosis and treatment of retroperitoneal/intra-abdominal STS, outlines treatment recom-mendations, and reviews the evidence to support the guidelines recommendations. J Natl Compr Canc Netw 2022;20(7):815???833 doi: 10.6004/jnccn.2022.0035