Igf2bp2 knockdown improves CCl4-induced liver fibrosis and TGF-β-activated mouse hepatic stellate cells by regulating Tgfbr1

Zhenyu Xu,Bo He,Yongfang Jiang,Min Zhang,Yi Tian,Ning Zhou,Yanwen Zhou,Mengxuan Chen,Min Tang,Jiashi Gao,Feng Peng

International Immunopharmacology（2022）

引用 6|浏览9

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摘要

•Igf2bp2 was up-regulated in CCl4-induced fibrotic liver and TGF-β-activated mHSCs.•Igf2bp2 knockdown improved CCl4-induced liver damage and suppressed TGF-β-activated mHSCs fibrotic changes.•Tgfbr1 was positively correlated with Igf2bp2.

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关键词

Igf2bp2,Tgfbr1,Hepatic fibrosis,Mouse hepatic stellate cells (mHSCs),PI3K/Akt pathway

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