Positive predictive value and trends of inferior petrosal sinus sampling (IPSS) in diagnosing cushing disease and ectopic ACTH secretion: A systematic review and meta-analysis

•There were significant changes in practice patterns over our epoch•Desmopressin stimulation provided improved outcomes relative to CRH stimulation•Desmopressin stimulation offers PPV equivalent to frontline methods with added benefit of lateralization•Future studies are necessary to further validate and improve lateralization capacity of desmopressin stimulation