Transcranial Photobiomodulation Add-On Therapy to Antiepileptic Drugs in Pediatric Epilepsy

Transcranial Photobiomodulation (tPBM) monotherapy with a wavelength of 808 nm attenuated Pentylenetetrazole (PTZ)-induced seizures in peripubertal rats. Furthermore, tPBM add-on therapy to low-dose Valproic Acid (VPA) yielded synergistic effects on PTZ-induced seizures while offset effects were shown when tPBM add-on therapy was applied to high-dose VPA. With the development of the optimal protocols of the tPBM add-on therapy to antiepileptic drugs such as VPA, synergistic therapeutic effects are expected to present in the prevention and treatments of pediatric epilepsy in the future.