Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease.

Anna C Riddell,Beatrix Kele,Kathryn Harris, Jon Bible,Maurice Murphy,Subathira Dakshina,Nathaniel Storey,Dola Owoyemi,Corinna Pade,Joseph M Gibbons,David Harrington,Eliza Alexander,Áine McKnight,Teresa Cutino-Moguel

Clinical Infectious Diseases（2022）

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摘要

The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is of public health concern in case of vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations that are associated with increased transmissibility and immune escape.

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Alpha variant,B.1.1.7,HIV-1 infection,SARS CoV-2,immunocompromised

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