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Desymmetric hydrolysis of prochiral imide for S-pregabalin synthesis by rationally designed d-hydantoinase

Feixia Liu,Jie Ren,Lu Guo,Yang Liu,De-Feng Li,Bo Yu

Green Chemistry（2022）

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Abstract
A one-step enzymatic desymmetrization process was developed to produce the direct chiral precursor for S-pregabalin synthesis with high yield and high eep value.
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Key words
desymmetric hydrolysis,synthesis,prochiral imide
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